学校案内 教員紹介

研究実績

【欧文原著】

1. Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T,
   Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y,
   Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi
   Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M,
   Tsuchida K.
   UBL3 modification influences protein sorting to small extracellular
   vesicles.
   Nat Commun. 26;9 (1) 3936-3949. doi:
   10.1038/s41467-018-06197-y. 2018
2. Naruse M, Ono R, Irie M, Nakamura K, Furuse T, Hino T, Oda K,
   Kashimura M, Yamada I, Wakana S, Yokoyama M, Ishino F,
   Kaneko-Ishino T.
   Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction
   and delayed parturition.
   Development. 141 (24) 4763-71 2014
3. Kaitsuka T, Katagiri C, Beesetty P, Nakamura K, Hourani S,
   Tomizawa K, Kozak J.A, Matsushita M.
   Inactivation of TRPM7 kinase activity does not impair its channel
   function in mice.
   Scientific Reports. Jul 17;4:5718. doi: 10.1038/srep05718. 2014
4. Kaitsuka T, Li ST, Nakamura K, Takao K, Miyakawa T,
   Matsushita M.
   Forebrain-specific constitutively active CaMKKα transgenic mice
   show deficits in hippocampus-dependent long-term memory.
   Neurobiol Learn Mem. 96 (2) 238-247 2011
5. Hino T, Oda K, Nakamura K, Tateno H, Toyoda Y, Yokoyama M.
   Accelerated modification of the zona pellucida is the primary cause
   of decreased fertilizability of oocytes in the 129 inbred mouse
   strain.
   Zygote. 19 (4) 315-22 2011
6. Saito K, Kakizaki T, Hayashi R, Nishimaru H, Furukawa T,
   Nakazato Y, Takamori S, Ebihara S, Uematsu M, Mishina M,
   Miyazaki J, Yokoyama M, Konishi S, Inoue K, Fukuda A,
   Fukumoto M, Nakamura K, Obata K, Yanagawa Y.
   The physiological roles of vesicular GABA transporter during
   embryonic development: a study using knockout mice.
   Mol Brain. 2010 Dec 30; 3: 40. 2010
7. Osada T, Ogino H, Hino T, Ichinose S, Nakamura K, Omori A, Noce
   T, Masutani M.
   PolyADP-ribosylation is required for pronuclear fusion during
   postfertilization in mice.
   PLoS One. 2010 Sep 2; 5 (9). pii: e12526. 2010
8. Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M.
   Tubulin polyglutamylation is essential for airway ciliary function
   through the regulation of beating asymmetry.
   Proc Natl Acad Sci U S A. 107 (23) 10490-10495 2010 (IF
   = 9.380)
9. Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki
   M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M,
   Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T.
   Comprehensive behavioral analysis of
   calcium/calmodulin-dependent protein kinase IV knockout mice.
   PLoS One. 2010 Mar 1;5(3):e9460.

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10. Kitamura K, Itou Y, Yanazawa M, Ohsawa M, Suzuki-Migishima
    R, Umeki Y, Hohjoh H, Yanagawa Y, Shinba T, Itoh M, Nakamura
    K.
    Three human ARX mutations cause the lissencephaly-like and
    mental retardation with epilepsy-like pleiotropic phenotypes in
    mice.
    Hum Mol Genet. 18 (19) 3708-3724 2009 (IF = 7.249)
11. Hino T, Oda K, Nakamura K, Toyoda Y, Yokoyama M.
    Low fertility in vivo resulting from female factors causes small
    litter size in 129 inbred mice.
    Reprod Med Biol. 8 157-161 2009
12. Shiura H, Nakamura K, Hikichi T, Hino T, Oda K,
    Suzuki-Migishima R, Kohda T, Kaneko-Ishino T, Ishino F.
    Paternal deletion of Meg1/Grb10 DMR causes maternalization of
    the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading
    to severe pre- and postnatal growth retardation.
    Hum Mol Genet. 18 (8) 1424-1438 2009 (IF = 7.249)
13. Sekita Y, Wagatsuma H, Nakamura K, Ono R, Kagami M,
    Wakisaka N, Hino T, Suzuki-Migishima R, Kohda T, Ogura A,
    Ogata T, Yokoyama M, Kaneko-Ishino T, Ishino F.
    Role of retrotransposon-derived imprinted gene, Rtl1, in the
    feto-maternal interface of mouse placenta.
    Nat Genet. 40 (2) 243-248 2008 (IF = 30.259)
14. Nakamura K, Ichise H, Nakao K, Hatta T, Otani H, Sakagami H,
    Kondo H, Katsuki M.
    Partial functional overlap of the three ras genes in mouse
    embryonic development.
    Oncogene. 27 (21) 2961-2968 2008 (IF = 7.216)
15. Ogawa M, Miyakawa T, Nakamura K, Kitano J, Furushima K,
    Kiyonari H, Nakayama R, Nakao K, Moriyoshi K, Nakanishi S.
    Altered sensitivities to morphine and cocaine in scaffold protein
    tamalin knockout mice.
    Proc Natl Acad Sci U S A. 104 (37) 14789-14794 2007 (IF
    = 9.380)
16. Yana I, Sagara H, Takaki S, Takatsu K, Nakamura K, Nakao K,
    Katsuki M, Taniguchi S, Aoki T, Sato H, Weiss SJ, Seiki M.
    Crosstalk between neovessels and mural cells directs the
    site-specific expression of MT1-MMP to endothelial tip cells.
    J Cell Sci. 120 (Pt 9) 1607-1614 2007 (IF = 6.247)
17. Iwashita S, Kobayashi M, Kubo Y, Hinohara Y, Sezaki M,
    Nakamura K, Suzuki-Migishima R, Yokoyama M, Satoh S, Fukuda
    M, Ohba M, Kato C, Adachi E, Song SY.
    Versatile roles of R-Ras GAP in neurite formation of PC12 cells and
    embryonic vascular development.
    J Biol Chem. 282 (6) 3413-3417 2007 (IF = 5.520)
18. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y,
    Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H,
    Mizushima N.
    Suppression of basal autophagy in neural cells causes
    neurodegenerative disease in mice.
    Nature. 441 (7095) 885-889 2006 (IF = 31.434)
19. Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka-Saito
    N, Hino T, Suzuki-Migishima R, Ogonuki N, Miki H, Kohda T,
    Ogura A, Yokoyama M, Kaneko-Ishino T, Ishino F.
    Deletion of Peg10, an imprinted gene acquired from a
    retrotransposon, causes early embryonic lethality.
    Nat Genet. 38 (1) 101-106 2006 (IF = 30.259)
20. Komine Y, Nakamura K, Katsuki M, Yamamori T.
    Novel transcription factor zfh-5 is negatively regulated by its own
    antisense RNA in mouse brain.
    Mol Cell Neurosci. 31(2) 273-283 2006 (IF = 3.934)
21. Hara T, Saito Y, Hirai T, Nakamura K, Nakao K, Katsuki M, Chida
    K.Deficiency of protein kinase Calpha in mice results in impairment
    of epidermal hyperplasia and enhancement of tumor formation in
    two-stage skin carcinogenesis.
    Cancer Res. 65 (16) 7356-7362 2005 (IF = 7.514)
22. Kassai H, Aiba A, Nakao K, Nakamura K, Katsuki M, Xiong WH,
    Yau KW, Imai H, Shichida Y, Satomi Y, Takao T, Okano T, Fukada
    Y.Farnesylation of Retinal Transducin Underlies Its Translocation
    during Light Adaptation.
    Neuron 47 (4) 529-539 2005 (IF = 14.170)
23. Tomemori Y, Ichiba M, Kusumoto A, Mizuno E, Sato D, Muroya S,
    Nakamura M, Kawaguchi H, Yoshida H, Ueno S, Nakao K,
    Nakamura K, Aiba A, Katsuki M, Sano A.
    A gene-targeted mouse model for chorea-acanthocytosis.
    J Neurochem. 92 (4) 759-766 2005 (IF = 4.500)
24. Hiratsuka S, Nakao K, Nakamura K, Katsuki M, Maru Y, Shibuya
    M.Membrane fixation of vascular endothelial growth factor receptor 1
    ligand-binding domain is important for vasculogenesis and
    angiogenesis in mice.
    Mol Cell Biol. 25 (1) 346-354 2005 (IF = 5.942)
25. Hiratsuka S, Kataoka Y, Nakao K, Nakamura K, Morikawa S,
    Tanaka S, Katsuki M, Maru Y, Shibuya M.Vascular Endothelial Growth Factor A (VEGF-A) Is Involved in
    Guidance of VEGF Receptor-Positive Cells to the Anterior Portion
    of Early Embryos.
    Mol Cell Biol. 25 (1) 355-363 2005 (IF = 5.942)
26. Sato M, Tabata T, Hashimoto K, Nakamura K, Nakao K, Katsuki
    M, Kitano J, Moriyoshi K, Kano M, Nakanishi S.Altered agonist sensitivity and desensitization of neuronal mGluR1
    responses in knock-in mice by a single amino acid substitution atthe PKC phosphorylation site.
    Eur J Neurosci. 20 (4) 947-955 2004 (IF = 3.385)
27. Chida K, Hara T, Hirai T, Konishi C, Nakamura K, Nakao K, Aiba
    A, Katsuki M, Kuroki T.Disruption of protein kinase Ceta results in impairment of wound
    healing and enhancement of tumor formation in mouse skincarcinogenesis.
    Cancer Res. 63(10) 2404-2408 2003. (IF = 7.514)
28. Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai KI,
    Masai H.Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death.
    EMBO J. 21(9) 2168-2179 2002 (IF = 8.295)
29. Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K,
    Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC,
    Katsuki M, Horie S.Pioglitazone improves the phenotype and molecular defects of a
    targeted Pkd1 mutant.
    Hum Mol Genet 11(15) 1731-1742 2002 (IF = 7.249)
30. Chusho H, Tamura N, Ogawa Y, Yasoda A, Suda M, Miyazawa T,
    Nakamura K, Nakao K, Kurihara T, Komatsu Y, Itoh H, Tanaka K,
    Saito Y, Katsuki M, Nakao K.Dwarfism and early death in mice lacking C-type natriuretic peptide.
    Proc Natl Acad Sci USA 98 4016-4021 2001 (IF = 9.380)
31. Kajiwara K, O-Wang J, Sakurai T, Yamashita S, Tanaka M, Sato
    M, Tagawa M, Sugaya E, Nakamura K, Nakao K, Katsuki M,
    Kimura M.Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis.
    Genes to Cells 6(2) 99-106 2001 (IF = 3.137)
32. Fukami K, Nakao K, Inoue T, Kataoka Y, Kurokawa M, Fissore RA,Nakamura K, Katsuki M, Mikoshiba K, Yoshida N, Takenawa T.
    Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.
    Science 292(5518) 920-923 2001 (IF = 28.103)
33. Tsuzuki T, Egashira A, Igarashi H, Iwakuma T, Nakatsuru Y,Tominaga Y, Kawate H, Nakao K, Nakamura K, Ide F, Kura S,Nakabeppu Y, Katsuki M, Ishikawa T, Sekiguchi M.Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
    Proc Natl Acad Sci USA 98 11456-11461 2001 (IF = 9.380)
34. Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A,Copeland NG, Gilbert DJ, Jenkins NA, Scully S, Lacey DL,
    Katsuki M, Asashima M, Yokota T.Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development.
    Development 128 3105-3115 2001 (IF = 6.812)
35. Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T,
    Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M.Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
    Oncogene 19 2951-2956 2000 (IF = 7.216)
36. Tamura N, Ogawa Y, Chusho H, Nakamura K, Nakao K, Suda M,Kasahara M, Hashimoto R, Katsuura G, Mukoyama M, Itoh H,Saito Y, Tanaka I, Otani H, Katsuki M, Nakao K.Cardiac fibrosis in mice lacking brain natriuretic peptide.
    Proc Natl Acad Sci USA 97 4239-4244 2000 (IF = 9.380)
37. Sunahara S, Nakamura K, Nakao K, Gondo Y, Nagata Y, Katsuki
    M. The oocyte-specific methylated region of the U2afbp-rs/U2af1-rs1 gene is dispensable for its imprinted methylation.
    Biochem Biophys Res Commun 268(2) 590-595 2000 (IF = 2.648)
38. Sugiyama T, Hirono M, Suzuki K, Nakamura Y, Aiba A, NakamuraK, Nakao K, Katsuki M, Yoshioka T.
    Localization of phospholipase Cbeta isozymes in the mouse cerebellum.
    Biochem Biophys Res Commun 265(2) 473-478 1999 (IF = 2.648)
39. Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K,Nakao K, Nakamura K, Katsuki M, Yamamoto T, Inoue JI.
    Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.
    Genes to Cells 4(6) 353-362 1999 (IF = 3.137)
40. Sato T, Oyake M, Nakamura K, Nakao K, Fukusima Y, Onodera O, Igarashi S, Takano H, Kikugawa K, Ishida Y, Shimohata T, Koide
    R, Ikeuchi T, Tanaka H, Futamura N, Matsumura R, Takayanagi T,Tanaka F, Sobue G, Komure O, Takahashi M, Sano A, Ichikawa Y, Goto J, Kanazawa I, Katsuki M, Tsuji S.
    Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patients.
    Human Molecular Genetics 8: (1) 99-106 1999 (IF =
    7.249)
41. Takada T, Yoshida K, Nakamura K, Nakao K, Tsujimoto G, Katsuki M, Sugano S.
    Expression of green fluorescent protein in transgenic mice.
    Methods Enzymol. 302 233-250 1999 (IF = 2.312)
42. Sugihara K, Nakatsuji N, Nakamura K, Nakao K, Hashimoto R, Otani H, Sakagami H, Kondo H, Nozawa S, Aiba A, Katsuki M.
    Rac1 is required for the formation of three germ layers during gastrulation.
    Oncogene 17 3427-3433 1998 (IF = 7.216)
43. Yoshikawa H, Taniguchi SI, Yamamura H, Mori S, Sugimoto M, Miyado K, Nakamura K, Nakao K, Katsuki M, Shibata N, Takahashi K.
    Mice lacking smooth muscle calponin display increased bone
    formation that is associated with enhancement of bone morphogenetic protein responses.
    Genes to Cells 3(10) 685-695 1998 (IF = 3.137)
44. Honda H, Oda H, Nakamoto T, Honda Z, Sakai R, Suzuki T, Saito T, Nakamura K, Nakao K, Ishikawa T, Katsuki M, Yazaki Y, Hirai H.
    Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas.
    Nat Genet 19(4) 361-365 1998 (IF = 30.259)
45. Mimura J, Yamashita K, Nakamura K, Morita M, Takagi T-N, Nakao K, Ema M, Sogawa K, Yasuda M, Katsuki M, Fujii-Kiriyama Y.
    Loss of teratogenic response to 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) in mice lacking the AH(dioxin)receptor.
    Genes to Cells 2 645-654 1997 (IF = 3.137)
46. Araki E, Nakamura K, Nakao K, Kameya S, Kobayashi O, Nonaka I, Kobayashi T, Katsuki M.
    Targeted disruption of exon 52 in the mouse dystrophin gene induced muscle degeneration similar to that observed in Duchenne muscular dystrophy.
    Biochem Biophys Res Commun 238 492-497 1997 (IF = 2.648)
47. Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M.
    K-Ras is essential for the development of the mouse embryo.
    Oncogene 15 1151-1159 1997 (IF = 7.216)
48. Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M, Nakanishi S.
    Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
    The Journal of Neuroscience 16(24) 7859-7867 1996 (IF = 7.452)
49. Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, Nakanishi S.
    Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.
    Science 273 645-647 1996 (IF = 28.103)
50. Nakamura K, Nakao K, Shibuya S, Shin RW, Gondo Y, Katsuki M, Tateishi J.
    Humanized prion protein knock-in by Cre-induced site-specific recombination in the mouse.
    Biochem Biophys Res Commun 222(3) 742-747 1996 (IF = 2.648)
51. Tsuzuki T, Sakumi K, Shiraishi A, Kawate H, Igarashi H, Iwakuma T, Tominaga Y, Zhang S, Shimizu S, Ishikawa T, Nakamura K,
    Nakao K, Katsuki M, Sekiguchi M.
    Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent.
    Carcinogenesis 17 1215-1220 1996 (IF = 4.930)
52. Yamaguchi H, Aiba A, Nakamura K, Nakao K, Sakagami H, Goto K, Kondo H, Katsuki M.
    Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
    Genes to Cells 1 253-268 1996 (IF = 3.137)
53. Tokita Y, Bessho Y, Masu M, Nakamura K, Nakao K, Katsuki M, Nakanishi S.
    Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells.
    Eur J Neurosci 8 69-78 1996 (IF = 3.385)
54. Masu M, Iwakabe H, Togawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi S.
    Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.
    Cell 80 757-765 1995 (IF = 31.253)
55. Gondo Y, Nakamura K, Nakao K, Sasaoka T, Ito K, Kimura M, Katsuki M.
    Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
    Biochem Biophys Res Commun 202 830-837 1994 (IF = 2.648)

【和文原著】

1. 斉藤亜矢、割田貴之、大久保朋一、津田道雄、中村健司、坂部貢、木村
   穣.鶏卵における Neuropathy Target Esterase 活性と有機リンの影響.
   臨床環境医学 20(1) 54-60 2011
2. 中村健司.
   標的遺伝子置換法を用いた p53 遺伝子の機能解析.
   新渡戸文化短期大学学術雑誌. ISSN 2186-5043 7 p1-9 2017

【欧文著書】

li>Takada T, Yoshida K, Nakamura K, Nakao K, Tsujimoto G, Katsuki M, Sugano S.
Expression of Green Fluorescent Protein in Transgenic Mice.
Methods in Enzymology 302 233-250 1999
1. Sato T, Yamada M, Oyake M, Nakao K, Nakamura K, Katsuki M, Takahashi H, Tsuji S.
   Transgenic mice harboring a full-length human DRPLA gene with
   highly expanded CAG repeats exhibit severe disease phenotype.
   American Journal of Human Genetics 65: (4) 154 1999
2. Sato T, Oyake M, Nakao K, Nakamura K, Katsuki M, Tsuji S.
   Transgenic mice harboring a full-length human mutant DRPLA gene reveal CAG repeat instability.
   American Journal of Human Genetics 61:(4) 1869 1997
3. Aiba A, Yamaguchi H, Nakamura K, Nakao K, Sakagami H, Goto K, Kondoh H, Katsuki M.
   Genetic analysis of Dopamine D2 receptor function in the pituitary and the brain.
   Gene Targeting and New Development in Neurobiology : Taniguchi Symposium on Brain Sciences No.19. (eds Nakanishi,S., Silva,AJ., Aizawa,S. and Katsuki,M.)
   pp127-1138 Jpn Sci Soc Press & S. Karger AG, 1996
4. Gondo Y, Nakamura K, Nakao K, Sasaoka T, Katsuki M.
   Construction and analysis of p53-deficient mice by a novel gene replacement system evidence for the loss of heterozygosity of the
   p53 gene in tumors.
   Journal of Cellular Biochemistry 195-195, suppl. 18A Jan 4 1994

【和文著書】

1. 中村健司
   生命の誕生に向けて 生殖補助医療（ART）胚培養の理論と実際（ES 細胞作製法）
   編集 日本哺乳動物卵子学会. 株式会社 近代出版. 2005年
2. 中村健司
   バイオゲノムを読む事典（ポストゲノム解析）
   三菱総合研究所、三菱化学生命科学研究所 編著. 東洋経済新報社.2004年
3. 中村健司
   遺伝子導入＆発現解析実験法（培養細胞への遺伝子導入法 エレクトロポレーション法（ES細胞））
   斉藤泉、菅野純夫編. pp22-26. 羊土社. 東京. 1997年
4. 権藤洋一、中村健司、中尾和貴、勝木元也
   Molecular Medicine（臨時増刊）マニュアル疾患モデルマウス（トランスジェニックマウスの基礎と方法論）（標的遺伝子組換えの新しい戦略 – 自在な標的遺伝子置換法）
   山村研一、勝木元也、相沢慎一編. pp54-59. 中山書店. 東京.
   1994年
5. 中村健司、中尾和貴、権藤洋一、勝木元也
   実験医学（自在な標的遺伝子置換法）
   実験医学 11. pp138-141. 羊土社. 東京. 1993年